Nanotechnology, the creation of new objects in nanoscale dimensions, presents a new revolution in modern science. Because the dimension of nanoscale materials is similar to cellular components such as DNA and proteins, their introduction to biological systems could be used to drastically modify the physicochemical properties of the material and induce large biological effects in organisms.
OmegaGenesis was founded to discover and manufacture suitable nano materials to manage human body functions at a nano scale. The size of the nano particles is about 1/100th of white blood cell and this allows nano operations at sub-cell levels. For the first time, it is possible to look inside a cell and only destroy cancerous part of the cell instead of entire cell.
OmegaGenesis is developing suitable nano-materials to manage human body functions at nano scale (the cell and sub-cell level) accelerating cellular-based biologic therapies where the growth of blood vessels determines the therapeutic outcome. These nano-materials will enable Physicians to treat disease at sub-cellular level in a non-destructive manner instead of treating the disease at the organ or tissue level.
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Angiogenesis is the formation of new blood vessels from pre-existing vessels. Angiogenesis is a normal process in growth and development, as well as in wound healing. However, this is also a fundamental step in the transition of tumors from a dormant state to a malignant state. Angiogenesis is a process controlled by certain chemicals produced in the body. Some of these chemicals stimulate cells to repair damaged blood vessels or form new ones. Other chemicals, called angiogenesis inhibitors, signal the process to stop. Therapeutic angiogenesis is the application of specific compounds or nano-materials which may inhibit or induce the creation of new blood vessels in the body in order to combat disease. The presence of blood vessels where there should be none may affect the mechanical properties of a tissue, increasing the likelihood of failure. The absence of blood vessels in a repairing or otherwise metabolically active tissue may retard repair or some other function. Several diseases (eg. ischemic chronic wounds) are the result of failure or insufficient blood vessel formation and may be treated by a local expansion of blood vessels, thus bringing new nutrients to the site, facilitating repair. Other diseases, such as age-related macular degeneration, may be created by a local expansion of blood vessels, interfering with normal physiological processes. |
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The presence of blood vessels where there should be none may affect the mechanical properties of a tissue, increasing the likelihood of failure. The absence of blood vessels in a repairing or otherwise metabolically active tissue may retard repair or some other function. Several diseases (eg. ischemic chronic wounds) are the result of failure or insufficient blood vessel formation and may be treated by a local expansion of blood vessels, thus bringing new nutrients to the site, facilitating repair. Other diseases, such as age-related macular degeneration, may be created by a local expansion of blood vessels, interfering with normal physiological processes.
Sprouting Angiogenesis
Sprouting angiogenesis was the first identified form of
angiogenesis. It occurs in several well-characterized stages.
First, biological signals known as angiogenic growth factors
activate receptors present on endothelial cells present in
pre-existing veins. Second, the activated endothelial cells begin
to release enzymes called proteases that degrade the basement
membrane in order to allow endothelial cells to escape from the
original (parent) vessel walls.
The endothelial cells then proliferate into the surrounding matrix
and form solid sprouts connecting neighboring vessels. As sprouts
extend toward the source of the angiogenic stimulus, endothelial
cells migrate in tandem, using adhesion molecules, the equivalent
of cellular grappling hooks, called integrins. These sprouts then
form loops to become a full-fledged vessel lumen as cells migrate
to the site of angiogenesis. Sprouting occurs at a rate of several
millimeters per day, and enables new vessels to grow across gaps
in the vasculature. It is markedly different from splitting
angiogenesis, however, because it forms entirely new vessels as
opposed to splitting existing vessels.
Intussusceptive Angiogenesis
Intussusception, also known as splitting angiogenesis, was first
observed in neonatal rats. In this type of vessel formation, the
capillary wall extends into the lumen to split a single vessel in
two. There are four phases of intussusceptive angiogenesis.
- First, the two opposing capillary walls establish a zone of contact.
- Second, the endothelial cell junctions are reorganized and the vessel bilayer is perforated to allow growth factors and cells to penetrate into the lumen.
- Third, a core is formed between the two new vessels at the zone of contact that is filled with pericytes and myofibroblasts. These cells begin laying collagen fibers into the core to provide an extracellular matrix for growth of the vessel lumen.
- Finally, the core is fleshed out with no alterations to the basic structure. Intussusception is important because it is a reorganization of existing cells. It allows a vast increase in the number of capillaries without a corresponding increase in the number of endothelial cells. This is especially important in embryonic development as there are not enough resources to create a rich microvasculature with new cells every time a new vessel develops.
Angiogenesis plays an important role in the growth and spread of cancer and malignancies. New blood vessels "feed" the cancer cells with oxygen and nutrients, allowing these cells to grow, invade nearby tissue, spread to other parts of the body, and form new colonies of cancer cells.
Nano-Material Research Enhances Angiogenesis
Cellular regeneration of blood cells, tissue, and organs is in its early stages and projected to yield real-world results by the end of this decade.
OmegaGenesis scientists are actively working with nano-materials to successfully advance the angiogenesis process for human applications. The goal is to identify potential human body management applications based on the research and testing in the nano-materials. OmegaGenesis' technology innovations are focused on the following areas:
1. Manufacturing angiogenic nano materials of well controlled size, shape, and biological activity
2. Developing commercial grade, safe manufacturing processes
3. Developing formulations for delivering nano materials in topical and internal applications
4. Establishing safe use of nano materials in human applications such as amputation prevention and hair growth.
Omega Genesis is developing applications based on these unique characteristics of nano materials for maintenance of the human body. Our goal is to supplement natural human body management and re-enable where some natural processes have stopped or diminished. Our approach can potentially provide for early and pre-disease intervention in most cases.
Additionally, our scientists are working with certain rare earth nano materials for use in imaging and have found these materials to possess physical properties, which make them suitable for medical imaging applications. We are also exploring the use of nano-materials with anti-angiogenesis properties.
The National Nanotechnology Initiative is the largest new federal science project in recent years. Researchers have successfully used gold nano-materials to deliver DNA molecules safely into cancer cells as part of a program to defeat cancer.
OmegaGenesis is in the business of developing new nano materials for clinical and medical applications. The Company's intellectual property includes the following areas: nano material with angiogenic properties; nano material with imaging properties; nano material for diagnostic use; nano material for drug delivery; nano material for anti-angiogenesis applications; manufacturing process for nano materials; size control IP for nano materials; and, synthesis and formulation of nano materials for topical and internal applications. OmegaGenesis has several international and country specific patent applications on record for rare earth nano particle.
- Formulation of Europium Hydroxide Nanorods
- Preparation and Characterization of Europium Hydroxide Nanorods
- Angiogenesis Application Enhancing Hair Growth
- Angiogenesis Application Enhancing Wound Healing